J. Anim Sci.
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J. Anim Sci. 1970. 31:789-793.
© 1970 American Society of Animal Science
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Effect of Subcutaneous Implantation of Resorcylic Acid Lactone on Performance of Growing and Finishing Beef Cattle1

T. W. Perry2, Martin Stob2, D. A. Huber3 and R. C. Peterson4

Purdue University, Lafayette, Indiana

Abstract

Resorcylic acid lactone (RAL) was originally isolated from corn infected with the fungus Gibberella zeae by Stob et al. (1962) who demonstrated that the compound was uterotropic in castrated female mice and anabolic in sheep. The chemical identity of RAL as a ß-resorcylate was proven by Urry et al. (1966). Preliminary work revealed that manipulation of the RAL molecule to a tetrahydro derivative resulted in an increase in uterotropic and anabolic activity. These studies also indicated that both forms of RAL were less uterotropically active than diethylstilbestrol (DES). Since the anabolic activity of stilbene estrogens seems to be proportional to their uterotropic activity (Perry et al., 1955), it seemed desirable to determine the growth stimulatory activity of tetrahydro RAL under a variety of conditions.

Experimental Procedure

Since RAL is a relatively new product, a variety of cattle feeding experiments were utilized to compare the effects of RAL and of diethylstilbestrol (DES).

Footnotes

1 Department of Animal Sciences Journal Paper No. 3913 Purdue University Agricultural Experiment Station. Research conducted at Purdue Lynnwood Agricultural Center and Miller-Purdue Agricultural Center.

2 Professor of Animal Sciences.

3 Superintendent, Miller-Purdue Agricultural Center.

4 Superintendent, Lynnwood-Purdue Agricultural Center.






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