J. Anim Sci.
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J. Anim Sci. 1970. 31:559-564.
© 1970 American Society of Animal Science
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Testicular Changes in Calves following Injection with Cadmium Chloride1

F. M. Pate2, A. D. Johnson3 and W. J. Miller2

University of Georgia, Athens

Abstract

In two experiments, Holstein bull calves received intravenous (IV), subcutaneous (SC), or intratesticular (IT) injections of CdCI2. In experiment 1, with 0.5 to 2.0 mg CdCl2/kg body weight administered IT or SC, there was pronounced edema at the injection site for all CdCl2 treatments. Edema was apparent in the scrotal area 2 to 3 hr. following IT injection and in the neck area 2 to 3 days after SC injections (dorsal neck region). Testes appeared normal for SC injected calves, but were hemorrhagic and necrotic in IT injected calves at each CdCl2 level. All IT injections resulted in pronounced destruction of testicular tissue, particularly around the injection point. In experiment 2, .05 to .20 mg CdCl2/kg of body weight was administered IT or IV. Pronounced testicular edema, tissue destruction immediately around the injection point, tubular breakdown and cessation of spermatogenesis followed IT injections. With IV dosing, tubular disorganization and impaired spermatogenesis occurred at each CdCl2 level. Feed intake was sharply reduced by both IV and IT CdCl2 injections and gains in body weight were reduced for IT dosed calves. The results of these studies suggest that cattle tissue is much more sensitive than that of goats or laboratory animals to CdCl2 injections. Injecting CdCl2 IV was more effective than IT or SC dosing in producing only testicular response with minimal side effects.

Footnotes

1 College of Agriculture Experiment Stations, Journal Series Paper No. 749 College Station. Supported in part by PHS Research Grant No. AM 07367-NTN from the National Institute of Arthritis and Metabolic Diseases.

2 Department of Dairy Science.

3 Department of Animal Science.






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