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Effects of Carbadox¹ on Performance and Carcass Traits of Growing Swine

Pfizer, Inc., Terre Haute, Indiana

Abstract

Studies at the Pfizer Research Laboratories (A.R. English, unpublished data) have indicated that carbadox, a synthetic organic compound, possessed in vitro and in vivo antibacterial activity against diverse bacteria. Antibacterial properties of this compound have been demonstrated in the control of a swine dysentery challenge (Davis, Libke and Kornegay, 1968) and Salmonella choleraesuis challenges in swine (R. H. Rainier, unpublished data). Recent trials have indicated that carbadox stimulated increased gains when fed to young pigs (Thrasher et al, 1967, 1969). In these experiments, carbadox was fed at 16 to 110 mg per kg of diet with was fed at 16 to 110 mg per kg of diet with per kilogram. Since carbadox was only fed to young pigs in the initial growth studies, this investigation was conducted to evaluate extended feeding of carbadox to growing swine with respect to its effects on pig performance and carcass traits at market weight.

¹ Methyl-3-(2-quinoxalinylmethylene) carbazate-N¹, N⁴-dioxide.

² The authors are indebted to F. W. Sigler, D.V.M. and R. H. Rainier, D.V.M. for necropsy of pigs which died for were removed from trial, and for gross pathological examination of pigs from trial 2. The assistance of Mr. G. R. Hart and associates in the care of experimental animals is greatly appreciated.