J. Anim Sci.
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J. Anim Sci. 1970. 30:812-818.
© 1970 American Society of Animal Science
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Chemical Additives in Rumen Fermentations: In Vitro Effects of Various Drugs on Rumen Volatile Fatty Acids and Protozoa

J. J. O'Connor1, G. S. Myers, Jr.1, D. C. Maplesden1 and G. W. Vander Noot2,3,

CIBA Corporation,4 Three Bridges, N. J. and Rutgers University

Abstract

Experiments were conducted to determine the effects of various compounds in an in vitro rumen fermentation system. Antibiotics, steroids, thiamine inhibitors, sulfonamides, a nitrofuran, antihistamines, antibacterials, antifungals, antiprotozoals and miscellaneous compounds were studied in vitro utilizing a hay-grain substrate and inoculum from a steer fed a hay-grain diet. Volatile fatty acids (VFA) were determined following a 6-hr, fermentation period. In general, the antibacterials, antifungals and the antiprotozoals had the most dramatic effects. Bis-[3-tert-butyl-4-(3-dimethylaminopropoxy)-6-methylphenyl]-sulfide dihydrochloride (Su-14,276), 3-{6-Tert-butyl-4-(1-[5-tert-butyl-4-(3-dimethylaminopropoxy)-o-tolyl]-butyl)-m-toloxy}-N, N-di-methyl-propylamine dihydrochloride (Su-15,-412), and 2-[p-(p-chloro-{alpha},{alpha}-dimethylbenzyl)-phenoxy]-triethylamine (Su-11,445) increased propionic acid thus lowering the A:P ratio while not affecting total VFA production. These compounds reduced protozoal activity. In contrast to these, 4, 7-phenanthroline-5, 6-dione inhibited VFA production and reduced1 protozoal activity.

Footnotes

1 Present address: Squibb Agricultural Research Center, Three Bridges, N. J. 08887.

2 Department of Animal Science, Rutgers—The State University, New Brunswick, New Jersey.

3 Appreciation is expressed to Mr. R. Luders and the staff of the Analytical Research and Development Division, CIBA Pharmaceutical Company for developing the method of volatile fatty acid analysis and the volatile fatty acid determinations.

4 Animal Health Division.






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Copyright © 1970 by the American Society of Animal Science.