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Excretion and Tissue Distribution of the Estrus-Synchronizing Compound 1--Methylallylthio-Carbamoyl-2-Methylthiocarbamoylhy-Drazine in Swine

U. S. Department of Agriculture

Abstract

The rates and routes of excretion of ¹⁴C following oral administration of 1-a-methylallyl-thiocarb- ¹⁴C-amoyl-2-methylthiocarbamoylhy-drazine (¹⁴C-Aimax) was studied with swine. Within 192 hr. after single oral dose, 92.9 and 5.5% of the ¹⁴C given was recovered in the urine and feces, respectively. The distribution of ¹⁴C within the body was determined 24 and 48 hr. after a single dose and 24 hr. after the last of three consecutive daily doses of ¹⁴C-Aimax. The relative concentration of ¹⁴C in various tissues and organs was similar in all cases. Within an animal, the ¹⁴C concentration in the thyroid was roughly 30 times that of the average for all other tissues and in the liver 2.5 times. All other tissue concentrations were of the same order of magnitude.

¹ Metabolism and Radiation Research Laboratory, Animal Husbandry Research Division, A.R.S., Fargo, North Dakota 58102.

² Ayerst Laboratories, 685 Third Ave., New York, N. Y. 10017.