J. Anim Sci.
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J. Anim Sci. 1970. 30:241-244.
© 1970 American Society of Animal Science
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Metabolic Effects of Growth Hormone and Diethylstilbestrol in Lambs. III. Metabolic Effects of Des1,2,

S. L. Davis3,4,, U. S. Garrigus and F. C. Hinds

University of Illinois, Urbana-Champaign5

Abstract

Studies were conducted to measure specific metabolic effects of DES administration to lambs to allow comparison with the metabolic effects previously reported for GH. It was observed that DES had effects similar to those of GH, that is, increased plasma glucose, insulin and nitrogen retention, and decreased PUN. These observations support the hypothesis that DES stimulates an increase in GH secretion.

These studies also suggest that the greatest part of the growth-promoting action of DES treatment in lambs may occur during the first 3 to 4 weeks of treatment. After that time continued DES treatment may result in a reduction of the stimulation of nitrogen retention seen during the first few weeks of treatment. These results suggest that it may be possible to achieve an even greater stimulation of gain with DES by an intermittent administration throughout the feeding period.

Footnotes

1 Supported in part by federal funds Hatch 20–346 and fay grants-in-aid from Moorman Manufacturing Company, Quincy, Illinois.

2 Data taken from thesis submitted to the Graduate College of the University of Illinois by the senior author in partial fulfillment of the requirements of the Ph.D. degree.

3 NIH Contract USPH GM0O653.

4 Present address: Medical College, University of Michigan, Ann Arbor.

5 Animal Science Department.






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