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Effects of an Unfractionated Pituitary Extract upon Cystic Ovaries and Nymphomania in Cows¹

University of Wisconsin^,3

Abstract

An unfractionated extract of sheep pituitary gland was injected intravenously into 96 cows with cystic ovaries. Eighty-one of these animals showed nymphomania at the time treatment was begun, but the symptoms disappeared in 72 after a single injection. Symptoms recurred during the observation period in 14 of them. Six of these recurrences were from the 12 animals that showed uterine or tubal pathology. Corpora lutea are known to have been formed in 74 of the 96 animals within 31 days after treatment. Normal estrus has been shown by 69 of them since the single injection. Of the 53 animals bred following a single injection out of 84 showing no recognized
uterine or tubal pathology 36 have become pregnant. Six of the 12 animals showing abnormalities of the genital tract have been bred but none have become pregnant.

Re-treatment of 16 animals either because the cysts persisted after the first injection or because they recurred sometime later resulted in 6 additional pregnancies, all among the animals with normal genital tracts. A third injection was given to 3 animals but resulted in no pregnancies.

Evidence is introduced in the discussion to the effect that these results show a positive action of the pituitary gonadotrophin upon cystic ovaries.

¹ Paper No. 330 from the Department of Genetics, Agricultural Experiment Station, University of Wisconsin. This work was supported in part by a grant from the Wisconsin Alumni Research Foundation.

² The cooperators in the field test made in this study have been Mr. T. C. Webster, Mr. Howard Clapp, Dr. Walter Wisnicky, Dr. Herbert Lothe, and Dr. J. T. Schwab. The authors are deeply appreciative of the whole-hearted cooperation of these men in the prosecution of the work. Some aid has been given to this study by Project 622-V: Trichomoniasis and other reproductive diseases of cattle. (B. A. Beach, in charge).

³ Departments of Genetics and Zoology.