J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Anim Sci. 1969. 29:504-508.
© 1969 American Society of Animal Science
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boling, J. A.
Right arrow Articles by Call, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boling, J. A.
Right arrow Articles by Call, J. L.

Secretion of Metabolites of Vitamin A and B-Carotene in the Bile of Sheep1,2,3,

J. A. Boling, G. E. Mitchell, Jr., C. O. Little, C. L. Fields and J. L. Call

University of Kentucky, Lexington

Abstract

Physiological quantities of 3H-vitamin A and 14C-beta-carotene were intravenously administered to bile-duct cannulated sheep. During 24-hr, collection periods, 21% of the injected dose of vitamin A was recovered in the bile. In the B-carotene trials, an average of 18% of the injected dose was observed in the bile during the collection periods. Secretory patterns of radioactivity in the bile were similar for the vitamin A and B-carotene trials. The major portion of the recovered radioactivity was secreted into the bile during the first 12-hr, of collection (87% for vitamin A vs. 83% for B-carotene). Infusion of radioactive bile from the vitamin A trials into the duodenum of an anesthetized sheep showed appreciable absorption of vitamin A metabolites. These data establish biliary secretion of vitamin A and B-carotene metabolites in the bile of sheep and suggest that the enterohepatic circulation plays an important role in the vitamin A metabolism of sheep.

Footnotes

1 This paper No. (68-5-130) published with the approval of the Director of the Kentucky Agricultural Experiment Station.

2 Tritium-labeled vitamin A was prepared and donated by Hoffman-LaRoche, Nutley, N. J. Carbon–14 labeled beta-carotene was furnished by Hoffman-LaRoche, Nutley, N. J. and Eli Lilly and Company, Indianapolis, Ind.

3 This investigation was supported in part by Public Health Service Research Grant No. AM13326-01 from the National Institute of Arthritis and Metabolic Diseases.

4 Packard Model 4322.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1969 by the American Society of Animal Science.