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Estimation of Growth Hormone Secretion Rate in Cattle¹

University of Missouri, Columbia , ; Washington University and and Monsanto Company, St. Louis

Abstract

The amount of growth hormone (GH) degraded (or synthesized) per day was calculated as the product of (a) the concentration of GH-P, (b) the rate of disappearance rate (K) of GH-P and (c) the volume of the space of distribution of GH (GHDS). The average GH-P level was found to be 15 mug. per ml., the K per day was 44.7 and the GHDS was 31.8 1. per animal. The average GH secretion rate (GHSR) was found to be 19.1 mg./day/animal.

Two methods were used for the estimation of GHSR and both methods gave comparable results. It is hoped that this technique can be widely used to gain a better understanding of the role of GH in lactation and bovine endocrinology.

¹ Contribution from Missouri Agricultural Experiment Station. Journal Series No. 5379. Approved by the Director.

² Dairy Husbandry Department, University of Missouri.

³ Present Address: Laboratory of Environmental Patho-Physiology, Desert Research Institute, Nevada Southern University, Boulder City and Department of Biological Sciences, Nevada Southern University, Las Vegas.

⁴ Department of Medicine, Washington University, St. Louis, Missouri.

⁵ Present Address: Department of Psychiatry and Neurology, University of Tokyo, Tokyo, Japan.

⁶ Monsanto Company, St. Louis, Missouri.