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Distribution of Parenterally Administered ⁴⁵Ca in Bones of Growing Pigs

Cornell University, Ithaca, New York

Abstract

Eighteen 4-week-old Yorkshire and Hampshire pigs were used in 2 experiments to follow the distribution of ⁴⁵Ca in different parts of the skeleton after intraperitoneal (experiment 1) or intravenous (experiment 2) injection. The ⁴⁵Ca concentration (microcuries of ⁴⁵Ca per mg. total Ca) of the nasal turbinate paralleled that of the proximal and distal ends of the humerus, reaching a peak after 6 hr. and remaining through day 4 followed by a decline from day 4 to 8 and a further decline from day 8 to 16. The shaft of the humerus remained at a constant ⁴⁵Ca concentration throughout the 16-day period, probably reflecting early uptake by the subperiostium and subsequent trapping of the isotope in deep layers of bone as accretion continued. The femur showed the same trend.

The first lumbar vertebra and mandible were similar in activity to the ends of the femur and humerus and to the nasal turbinates at each time interval. The teeth showed the lowest activity and the frontal bone was intermediate.

There was a rapid disappearance of ⁴⁵Ca from the blood following intraperitoneal injection, but a small amount persisted even 16 days after injection, probably reflecting reentry into the circulation after removal from bone during remodeling.

Fecal and urinary losses of ⁴⁵Ca were continuous over a 16-day period and represented approximately 10% (5% in feces, 5% in urine) of the amount injected.

The similarity of ⁴⁵Ca uptake by the nasal turbinate and by the growth plates of long bones suggests that areas of active bone growth in different parts of the skeleton of the pig have similar turnover rates. The nasal turbinate, a tubular cancellous bone, may, therefore, be more susceptible to excessive resorption than the long bone as an organ even though no more susceptile than the growth plate of long bones as a tissue.

¹ Department of Animal Science, New York State College of Agriculture.

² Department of Pathology, New York State College of Veterinary Medicine.

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