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Appetite Suppression in Hamsters and Swine Fed a Dithiocarbamoylhydrazine (ICI 33828)^{1, 2, 3,}

University of Wisconsin, Madison⁵

Abstract

Eighty-two hemicastrate male hamsters were assigned at random to be fed for 6, 7 or 8 days various doses of ICI 33828 in five different experiments. Twenty gilts were assigned at random to be administered orally or intramuscularly 250 mg./day of ICI 33828 for 14 days. Hamsters and pigs exhibited a similar suppression of appetite and bodyweight gain. Route of administration in pigs did not significantly affect any of the parameters measured.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station.

² Dithiocarbamoylhydrazine (ICI 33828), Ayerst Laboratories Incorporated, New York, New York.

³ Supported in part by funds from Tri-State Breeders Cooperative, Westby, Wisconsin; The American Meat Institute, Chicago, Illinois; and Murphy Products Company, Burlington, Wisconsin.

⁴ Fellow N.I.H. during experiment.

⁵ Department of Meat and Animal Science Paper No. 506.