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Diet Consumption, Bodyweight Change, Estrus Inhibition and Reproductive Performance in Gilts Fed a Dithiocarbamoylhydrazine (ICI 33828)^{1, 2, 3,}

University of Wisconsin, Madison⁵

Abstract

Fifty-eight gilts that had exhibited at least one previous estrus were assigned randomly to be started on treatment on day 3, 13 or 18 of the estrous cycle and fed 0, 58, 116 and 232 mg. of dithiocarbamoylhydrazine (ICI 33828) in 1.82 kg. of feed per day for 16 days.

The number of corpora lutea, 25-day litter size, percent pregnant at 3- and 25-day gestation, 3-day percent fertility and 2 5-day percent embryo survival were not significantly affected by dose levels nor by the day of cycle at which treatment began. Litter size at 3-days gestation was significantly less when gilts were fed 232 mg.; however, there was significant interaction between dose level and the day of cycle ICI 33828 feeding started. Embryo plus placenta weight and amniotic fluid weight at 25-days gestation were not significantly influenced by feeding 116 mg. per day. The number of secondary or visible follicles <6 mm. was significantly fewer at 3-days gestation when gilts were started on treatment on day 3 of the estrous cycle and significantly greater at 25-days gestation. The day of cycle on which treatment was started and the dose level significantly reduced bodyweight gains during the 16-day feeding period. Significantly longer intervals from withdrawal of the drug to estrus were evident as dose level increased.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station.

² Dithiocarbamoylhydrazine (ICI 33828), Ayerst Laboratories Incorporated, New York, New York.

³ Supported in part by funds from Tri-State Breeders Cooperative, Westby, Wisconsin; The American Meat Institute, Chicago, Illinois; and Murphy Products Company, Burlington, Wisconsin.

⁴ Fellow, N.I.H., during experiment.

⁵ Department of Meat and Animal Science, Paper No. 503.