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Effects of Selenium and Vitamin E on Nutritional Muscular Dystrophy in Lambs^{1, 2,}

University of Wisconsin⁴, >Madison

Abstract

Sixty-four lambs were weaned at two days of age and were used in two factorial studies with vitamin E and selenium. A semi-purified diet in which Torula yeast was the source of protein was prepared and fed as a milk substitute. When this diet was fed, selenium and vitamin E had an additive effect on reduction of blood levels of GOT, increasing survival time, and decreasing the ratio of urinary creatine to creatinine excretion. Vitamin E reduced LDH values and prevented hemolysis of red blood cells by dialuric acid. Selenium enhanced hemolysis which was probably related to increased survival and resulting depletion of vitamin E stores. Selenium increased the growth rates of lambs in one experiment while vitamin E had no effect in either experiment.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station.

² Supported in part by the Graduate School with funds supplied by the Wisconsin Alumni Research Foundation and by funds from the Selenium Tellurium Development Association.

³ Present address: Department of Animal Science, Iowa State University, Ames.

⁴ Department of Meat and Animal Science and Department of Biochemistry.