J. Anim Sci.
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J. Anim Sci. 1968. 27:178-184.
© 1968 American Society of Animal Science
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Renal Clearance of P-Aminohippuric Acid and Inulin in Dairy Cattle1

F. L. Mangelson, L. E. Harris, J. L. Shupe and D. A. Greenwood2

Utah State University, Ephraim and Logan

Abstract

Studies were made on four dairy cows to determine if p-aminohippuric acid (PAH) and inulin could be used to obtain reliable kidney clearances. The extent of conjugation and the conjugation products of PAH were ascertained. Recovery of p-aminophippuric acid and inulin in the urine of the four experimental cows during a period of 10 hr. or longer after injection averaged 92 and 82% of the injected doses.

The results of these experiments indicate that PAH and inulin can be used, with a single intravenous injection into a cow, to give reliable data for the calculation of kidney clearances of these chemicals. The single intravenous injection of the test chemicals and calculation of the mean serum concentration from the serum decay curve-kinetic type data is much simpler and is a distinct advantage over giving a primary dose and continuous infusion during the clearance period, especially in large animals. The PAH and inulin clearances are generally considered to measure effective renal plasma flow and glomerular nitration rate, respectively.

Footnotes

1 This research was supported in part by a grant-in-aid from Columbia-Geneva Division, United States Steel Corporation, Provo, Utah. This report is part of a large cooperative project; other leaders working on it included G. E. Stoddard, G. Q. Bateman, M. L. Miner, H. M. Nielsen and L. E. Olsen. Journal Paper No. 567.

2 Professor of Chemistry, Utah State University (Snow College Branch) at Ephraim; Professor of Animal Science; Professor of Veterinary Science; and Professor of Biochemistry and Pharmacology. The authors wish to thank Alice Denney for her help in preparing the manuscript.






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Copyright © 1968 by the American Society of Animal Science.