J. Anim Sci.
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J. Anim Sci. 1967. 26:1445-1449.
© 1967 American Society of Animal Science
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Inhibitory Effect of Amphetamine on Feed and Water Intake in Sheep1

Asok Nath Bhattacharya and R. G. Warner

Cornell University2, Ithaca, New York

Abstract

Three experiments were conducted to study the inhibitory effect of dexedrine (d-amphetamine sulphate) on feed and water intake in fed and fasted sheep.

Yearling wethers were fed a 50% concentrate, 50% ground hay ration ad libitum twice daily for a period of 2 hours. Amphetamine in aqueous solution was injected subcutaneously at the level of 0, 1.5 or 2.5 mg./kg. bodyweight 1 hr. before the morning feeding. A depression (P<.01) of daily feed intake from934 gm. per feeding in the control animals to 70S gm. and 350 gm. was observed, respectively in the 1.5 and 2.5 mg. amphetamine groups. No after effect on intake was noticed at the next feeding. Water intake dropped (P<.01) following injection of the higher level. In a second experiment involving four sheep, no significant increase in ad libitum feed intake was observed following increasing length of fasting periods of 24, 37, or 48 hr., when compared with that of the control group (17 hr. since previous feeding). Amphetamine injection (subcutaneous) at a level of 2 mg./kg. of bodyweight depressed feed intake significantly (P<.01) from 628 to 221 gm., 665 to 293 gm., 602 to 401 gm. and 647 to 458 gm., respectively, in the control (17-hr.), 24-, 37- and 48-hr, fasting groups. The appetite-depressing effect was thus partially counteracted by increased hours of fasting. Arterial and venous levels of glucose and steam volatile fatty acids were higher in the amphetamine group, as found in experiment three.

Footnotes

1 This project was supported in part by a grant from the United States Department of Agriculture CSRS No. 427-15-17. The authors gratefully acknowledge the gift of the Dexedrine from the Smith, Kline and French Laboratories, Philadelphia, Pennsylvania. The assistance of Messrs. Robert Brokaw, Lester Brock for their care of the experimental animals and Mr. Marlin Hiller for assistance with the chemical analysis is also acknowledged with thanks.

2 Department of Animal Science.






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Copyright © 1967 by the American Society of Animal Science.