J. Anim Sci.
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J. Anim Sci. 1967. 26:1017-1023.
© 1967 American Society of Animal Science
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Effect of Exogenous Prednisolone and Methylprednisolone upon Plasma 17-Hydroxycorticosteroid Levels and Some Porcine Muscle Characteristics1

D. G. Topel2 and R. A. Merkel3

Michigan State University, East Lansing

Abstract

Three experiments were conducted to study the effect of exogenous adrenal steroids upon plasma 17-hydroxycorticosteroid (17-OHCS) levels, sodium and potassium contents and several other porcine muscle characteristics. Forty-eight market weight pigs (81 to 98 kg.) were fed or injected intramuscularly with either prednisolone or methylprednisolone. Adrenal atrophy and lower levels of plasma 17-OHCS were observed at the levels of administration and duration studied in the three experiments. Quantity of sarcoplasmic and myofibrillar proteins extracted from prednisolone or methylprednisolone treated pigs in all three experiments was not significantly (P >.05) different from controls. Suppressed plasma 17-OHCS levels, induced by either prednisolone or methylprednisolone, did not result in the development of PSE musculature in any of the pigs in these three experiments. Daily prednisolone injection (200 mg./day) for 7 days resulted in significantly (P<.05) higher muscle NPN values. In experiment 2, the rate of postmortem pH change of the l. dorsi muscles was studied and observed to be slightly suppressed for prednisolone injected pigs as compared to that for the controls. Also, prednisolone exhibited a slight sodium retaining effect upon muscle, while methylprednisolone resulted in muscle sodium diminution. Neither steroid significantly (P>.05) altered potassium level of the l.1 dorsi muscle.

Footnotes

1 Journal article 3963, Michigan Agricultural Experiment Station, East Lansing.

2 Present address: Department of Animal Science, Iowa State University, Ames.

3 The authors wish to express their appreciation to The Upjohn Co., Kalamazoo, Michigan, for supplying the prednisolone and methylprednisolone for this study.






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Copyright © 1967 by the American Society of Animal Science.