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Responses in Hypophysectomized Rats to Cavernous Sinus Plasma from Estrogen-Treated Wethers^{1, 2,}

Oregon State University, Corvallis³

Abstract

Five experiments were conducted with gonadectomized sheep to study the influence of daily estrogen treatment on plasma levels of various pituitary activities, with the greatest emphasis on gonadotropic activity. The plasma was assayed as either raw plasma or plasma fractions in immature hypophysectomized female rats. The estrogens studied were diethylstilbestrol and estradiol benzoate.

A significant depression in plasma gonadotropic activity to all estrogen treatments was clearly demonstrated by the ovarian and uterine weight responses in the test subjects. Histological study of the ovaries indicated that the depression always involved plasma FSH activity and usually plasma ICSH activity. The gonadotropic depression was apparent for periods of time following estrogen withdrawal, as well as evident during treatment. Adrenal weight and epiphyseal plate responses of the assay animals to the injected plasma did not establish marked trends as did the gonadal responses.

The findings of this study are discussed in relation to current concepts of estrogen and pituitary interactions.

¹ Invited paper presented at the 58th Annual Meeting of the American Society of Animal Science, Rutgers—The State University, New Brunswick, New Jersey. This investigation was supported by U.S.P.H.S. Research Grant AM-08038 and is technical paper number 2203 from the Oregon Agricultural Experiment Station.

² The authors wish to acknowledge the cooperation of C. W. Fox and the assistance of J. J. Reeves in the conduction of this study. The assistance and advice of K. E. Rowe, Experiment Statistician, in statistical analyses is also acknowledged.

³ Department of Animal Science.