J. Anim Sci.
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J. Anim Sci. 1967. 26:540-544.
© 1967 American Society of Animal Science
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Variations in Biosynthesis of Progesterone and Response to Interstitial Cell-Stimulating Hormone In Vitro in Bovine Corpora Lutea1

E. K. Inskeep2, C. E. Johnson2, J. E. McNary3 and P. F. Hall4

West Virginia University, Morgantown and University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Eighteen corpora lutea were obtained from 10 lactating dairy cows of three breeds at three stages of the estrual cycle. Synthesis of progesterone in vitro in the presence of cholesterol-7 a -H3 and in the presence or absence of ICSH was studied in these glands.

The response to ICSH in vitro was influenced by the age of the corpus luteum. Two criteria of ICSH activity, namely: (1) an increase in progesterone synthesis during incubation with ICSH, and (2) increased conversion of cholesterol-7 a -H3 to progesterone-H3 produced by ICSH, were greater at days 11 to 13 than with younger or older glands. Corpora lutea obtained at days 19 and 20 did not respond to ICSH.

Breed of cow appeared to influence corpus luteum weight and concentration of progesterone following incubation and, perhaps, also the conversion of exogenous tritiated cholesterol to progesterone.

Footnotes

1 Published with the approval of the director of the West Virginia Agricultural Experiment Station as Scientific Paper No. 907. Supported in part by project Hatch 197 (NE-41) and in part by USPHS Grant AM 06459-03 and American Cancer Society Grant 951-638-9.

2 Department of Animal Industry and Veterinary Science, West Virginia University.

3 Department of Biochemistry, University of Pittsburgh.

4 Department of Physiology, University of Pittsburgh.






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Copyright © 1967 by the American Society of Animal Science.