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Anabolic Response and Catecholamine Excretion following Isocarboxazid Administration to Pigs¹

Canada Department of Agriculture, Nappan, Nova Scotia

Abstract

A series of five 4- to 11-week nitrogen balance experiments were conducted with forty-five 50- to 70-kg. pigs to study the effect of isocarboxazid given alone, or in combination with nicotine sulfate or with nicotine sulfate and glycocyamine. Pigs receiving isocarboxazid retained less nitrogen than controls consuming the same amount of feed. Once the drug was withdrawn, they not only regained the lost nitrogen but continued to retain nitrogen at a higher level than controls. This anabolic response could be triggered by giving isocarboxazid for periods of 2 to 4 weeks. Pigs excreted large amounts of epinephrine and norepinephrine in the urine during the administration of the drug and for several weeks thereafter. Nicotine and glycocyamine had little or no supplementary effect to that of the isocarboxazid except that nicotine alone tended to intensify the successive depletion and repletion of body nitrogen. Digestibility of dry matter and protein were depressed while the drug was being given and for several weeks thereafter. Carcasses of 4 pigs that retained more nitrogen than controls in one experiment contained 4% more protein and 8% less fat, but the differences were not significant. Carcass analysis also failed to show significant differences between 8 weanling pigs and their pair-fed, littermates which received isocarboxazid for the first 2 weeks of a 10-week feeding period.

¹ Contribution No. 200. Division of Animal Science, Research Branch, Canada Department of Agriculture, Nappa, Nova Scotia.

² The author wishes to acknowledge the assistance of the Canada Department of Agriculture, Production and Marketing Branch, Livestock Division, Moncton, New Brunswick, for supervising the slaughter and scoring of the pigs. Isocarboxazid was supplied through the courtesy of Hoffman-La Roche Ltd., Montreal. The technical assistance of R. M. Grant, E. C. A. Johnson, R. T. Ripley, H. A. Harrison, J. D. Nelson and J. G. Allen is gratefully acknowledged.