J. Anim Sci.
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J. Anim Sci. 1966. 25:1154-1158.
© 1966 American Society of Animal Science
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Effect of Exogenous Goitrogens upon Some Physical and Biochemical Properties of Porcine Muscle and Adrenal Gland1

D. G. Topel2 and R. A. Merkel3

Michigan Agricultural Experiment Station, East Lansing

Abstract

This study was conducted to determine the effects of two goitrogens, methylthiouracil and tapazole, upon some physical and biochemical properties of porcine muscle. Twelve pigs were included in experiment 1 to study the effect of tapazole. In experiment 2 both goitrogens were fed for 10 and 21 days prior to slaughter. Both tapazole and methylthiouracil produced hypertrophy of the thyroid gland to approximately the same degree, but methylthiouracil had a more pronounced effect upon adrenal weight than tapazole. L. dorsipH, myofibrillar and sarcoplasmic protein extractability, nonprotein nitrogen and sodium and potassium levels were quite similar when tapazole- and methylthiouracil-treated pigs were compared to controls. Some methylthiouracil-fed pigs, however, developed slightly pale, soft, exudative (PSE) ham muscles, especially the gluteus medius, whereas tapazole-fed pigs had normal-colored, firm and dry appearing ham musculature. Goitrogenically-induced hypothyroidism per se apparently had little effect upon the ultimate physical and biochemical properties of porcine muscle. Plasma 17-OHCS levels, although lower among the goitrogen-fed pigs than controls, were not significantly different.

Footnotes

1 Journal Article 3 794, Michigan Agricultural Experiment Station, East Lansing, Michigan.

2 Present address: Department of Animal Science, Iowa State University, Ames, Iowa.

3 The authors wish to express appreciation to Eli Lilly Co.,Indianapolis, Ind., for supplying the tapazole used in this study.






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Copyright © 1966 by the American Society of Animal Science.