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Structural Requirements for the Growth Response of Certain Estrogens in Ruminants^{1, 2,}

University of Missouri,^,4 Columbia

Abstract

Four experiments were conducted with growing lambs to determine the structural requirements for the growth and nitrogen balance stimulation effects of estrogens in ruminants. The administration of certain diphenylethylenes indicates that estrogenic activity related to hydroxyl group substitution is not a requirement for this response. Transstilbene appears to give a similar response and is essentially non-estrogenic. The growth response is tentatively assigned to the presence of two properly spaced phenyl groups.

¹ Contribution from the Missouri Agricultural Experiment Station. Journal Series Number 2807. Approved by the Director.

² This investigation was supported by Public Health Service Research Grant 03292, from the National Institutes of Health.

³ Assistance rendered by J. Johnson is gratefully acknowledged.

⁴ Department of Animal Husbandry.