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Further Studies on the Anti-Estrogenic Activity of Yellow Pine Needles¹

University of British Columbia,^,3 Canada

Abstract

The anti-estrogenic activity of yellow pine needles was assessed by using a 6-hr, bioassay procedure employing the laboratory rat. The effect of estradiol-17β on the uterine tissue of ovariectomized animals was diminished or inhibited by the simultaneous injection of prepared extracts of yellow pine needles. The active substance was eluted from a celite-chloroform concentrate mixture with ethyl acetate. Amorphous crystals formed during the cooling of the ethyl acetate eluant failed to exhibit anti-estrogenic activity even at an administration level of 50 gm. dry matter equivalent of the original plant material.

¹ This study was assisted financially by The Population Council, Inc., Rockefeller Institute, New York, N. Y.

² The authors acknowledge the assistance of Miss Jennia Biely and L. Holmes in carrying out this study.

³ Division of Animal Science.

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