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Limb Development in Prenatally Irradiated Cattle, Sheep and Swine¹

Agricultural Research Laboratory, University of Tennessee, Oak Ridge^,2

Abstract

Limb primordia of cattle, sheep, and swine fetuses were exposed to approximately 200 r of gamma irradiation at 27 to 34, 20 to 25, and 15 to 24 days of prenatal development, respectively. Limb development in swine was not affected at the stages studied, but limbs of cattle and sheep were affected with varying degrees of severity during the intervals of 31 to 34 (cattle) and 22 to 25 (sheep) days of gestation.

The apparent critical period for induction of abnormalities of the forelimbs was day 32 for the bovine and day 23 for the ovine. Pelvic limbs of both species probably reach their point of greatest radiosensitivity 12 to 24 hr. later than the thoracic limbs.

¹ This manuscript is published with the permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville.

² Operated by the Tennessee Agricultural Experiment Station for the U. S. Atomic Energy Commission under Contract No. AT-40-1-GEN-242.

³ The authors give thanks to D. F. Johnson and F. W. Sigler for performing the autopsies and to R. A. Reynolds and P. R. Welch for managing the irradiations.