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Toxicity of Cupric Sulfate for Beef Cattle¹

Florida Agricultural Experiment Station,^,4 Belle Glade

Abstract

Twenty Hereford x Brahman steers were divided into five groups of four animals each. The groups were allotted randomly to daily levels of 0.5, 1.0, 2.0, 4.0 and 8.0 gm. of CuSO₄, administered in a gelatin capsule. CUSO₄ administered in this manner was not toxic to the cattle. Increasing CUSO₄ levels to 0.75, 1.5, 3.0, 6.0 and 12.0 gm. did not create toxic syndromes.

However, when the 12.0 gm. level was administered in a water drench the CUSO₄ was toxic and resulted in death of two experimental animals in 65 days. Death was preceded by a loss in body weight, hemoglobinuria, decrease in blood hemoglobin and packed cell volume and a sharp increase in liver Cu levels. The anatomical-pathological diagnosis was toxic hepatitis and nephritis, splenic congestion with hemosiderosis and catarrhal enteritis.

¹ Florida Agricultural Experiment Station Journal Series No. 1475.

² Address: Diagnostic Laboratory, Florida Department of Agriculture, Kissimmee, Fla.

³ Address: Everglades Animal Hospital, Belle Glade, Florida.

⁴ Everglades Experiment Station, Belle Glade, Florida. Appreciation is expressed to E. Tomeu, J. V. McLeod, Mack Barnwell, L. V. Morris, and others who assisted in these studies.

These studies were supported in part by a grant-in-aid from Moorman Manufacturing Company, Quincy, Illinois. Reagent grade copper sulfate was furnished by Tennessee Corporation, Atlanta, Georgia.

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