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Reliability of the Liver Biopsy Technique for Estimating Hepatic Vitamin A^{1, 2, 3,}

University of Arizona, Tucson

Abstract

The variation in hepatic vitamin A content of 4 sampling sites in 96 livers ranging in storage from 2–5375 meg. per gm. was measured to determine the reliability of the liver biopsy technique as an estimate of the actual hepatic vitamin A storage. Some significant differences in storage were noted between sites but these differences did not materially decrease the accuracy of the sample as compared with other groups with nonsignificant site variation. It was determined that a liver sample obtained by the aspiration biopsy technique had a confidence interval of ±62.0% when expressed as a percent of the observed value if the vitamin A level of the liver was below 30 meg. per gm. The confidence interval for biopsy sample values in the liver storage range of 40 to 160 meg. vitamin A per gm. liver tissue would not exceed ±21.5%.

¹ Arizona Agricultural Experiment Station Technical Paper No.659.

² The authors acknowledge the assistance of Henry Tucker with the statistical analysis of the data.

³ This study was supported in part by U. S. Public Health Service Grant A-1799.