J. Anim Sci.
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J. Anim Sci. 1962. 21:226-231.
© 1962 American Society of Animal Science
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Reproductive Performance of Female Mink Fed Stilbestrol1

Richard M. Shackelford and Robert L. Cochrane2, 3,

University of Wisconsin, Madison

Abstract

Female mink were fed various levels of stilbestrol daily up to 10 months (beginning 7 months prior to breeding). It was found that 10 ug. of stilbestrol per day increased the incidence of complete sterility but had no apparent effect on the litter size of those females that whelped. The females affected by the daily 10 ug. dosage of stilbestrol seemed to recover completely the year subsequent to discontinuance of treatment. Doses of 6 ug. per day or less did not appear to have a deleterious effect on reproductive performance but some levels appeared to increase kit survival after birth.

Stilbestrol fed to yearling females at the level of 100 ug. on 3 days each in August, September, October and November did not appear to affect reproduction.

Footnotes

1 Paper from the Division of Genetics No. 843, published with the approval of the Director of the Agricultural Experiment Station. This work was done cooperatively between the Wisconsin Agricultural Experiment Station and the Sheep and Fur Animal Research Branch, U.S.D.A. and was supported in part by the latter agency.

2 Present address: Division of Pharmacology, Food and Drug Administration. Department of Health. Education and Welfare. Washington 25, D. C.

3 We wish to thank Eli Lilly & Co. for the generous supply of diethylstilbestrol and to express our appreciation to W- B. Fortune for running a mouse uterine weight assay on our stock stilbestrol solution at the conclusion of the experiments.






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Copyright © 1962 by the American Society of Animal Science.