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Residue Studies in Beef Tissues Following Oral Administration of Methimazole¹

Iowa State University, Ames

Abstract

Goitrogenic assays of various beef tissues from steers fed 400, 600 and 800 mg. of methimazole daily for 79 days revealed no detectable goitrogenic residues in the lean, fat, liver, kidney and tripe tissues. Estrogenic assays of lean and fat tissues indicated that the simultaneous feeding of methimazole and stilbestrol added no estrogenicity to beef tissues. The isotope technique developed in this study to measure goitrogenic activity of beef tissues utilized the "rebound" effect noted in uptake of I¹³¹ when the initially blocked thyroid becomes "unblocked" by removal of goitrogen from the assay diet. This technique did not necessitate fine dissection of the thyroid from surrounding tissue and proved to be at least twice as sensitive as I¹³¹ uptake measurements taken when the chicks were still on goitrogenic diets at the time of sacrifice.

¹ Journal Paper No. J-4192 of the Iowa Agricultural and Home Economics Experiment Station, Ames, Iowa, Project No. 869.

² Present address: Rockefeller Foundation, Mexico City, Mexico.

³ Present address: General Analysis Corporation, Los Angeles, California.