J. Anim Sci.
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J. Anim Sci. 1962. 21:132-136.
© 1962 American Society of Animal Science
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Induced Estrus in Anestrous Ewes by Use of Progestogens and Follicle Stimulating Hormone1,2,

V. G. Pursel and E. F. Graham

University of Minnesota, St. Paul3

Abstract

A high incidence of estrus (91.3%) and ovulation (98.4%) was successfully induced in anestrous ewes receiving progesterone pretreatment for 9 to 19 days and a single injection of 20 mg. to 50 mg. FSH. Significantly greater variation (P <0.01) in ovulation rate occurred when FSH was administered 24 hours instead of 48 hours after the last progesterone injection.

Oral administration of 6 methyl-17-acetoxy-progesterone for 12 days successfully replaced progesterone injections as the pretreatment for inducing estrus. Eighty percent of the anestrous ewes receiving 10 mg., 30 mg. and 60 mg. 6-methyl-17-acetoxyprogesterone once daily for 12 days and a single 25 mg. FSH injection exhibited estrus within 48 hours.

Injection of 25 mg. FSH without pretreatment induced estrus in 17.6% of the 17 treated ewes.

A 12-day interval between the 125 mg. 17-hydroxyprogesterone-17-caproate injection and the 25-mg. FSH injection resulted in estrus induction in 3 of the 4 ewes treated. Intervals of 8 and 10 days between injections were less satisfactory.

Footnotes

1 Scientific Journal Series Paper No. 4639, Minnesota Agricultural Experiment Station.

2 Gratitude is expressed to the Louis and Maud Hill Foundation for financial support; to M. E. Davenport, Armour Pharmaceutical Company, Kankakee, Illinois, for the Pituitary Gonadotropins; to R. A. Gessert, The Upjohn Company, Kalamazoo, Michigan, for the "Provera", 6-methyl-17-acetoxyprogesterone; and to A. D. Rankin, E. R. Squibb and Sons, New Brunswick, New Jersey, for furnishing the "Delalutin", 17-hydroxyprogesterone-17-caproate.

3 Department of Dairy Husbandry.






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