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Arsanilic Acid as a Therapeutic and Prophylactic Agent for Hemorrhagic Dysentery

Abbott Laboratories, North Chicago, Illinois^,2

Abstract

Data are presented from 3 experiments involving 277 pigs which were infected with hemorrhagic dysentery either through a natural outbreak or artificially. The treatment of this disease with 100 ppm arsanilic acid (AA), 200 ppm AA, or 250 ppm AA in the feed or 175 ppm sodium arsanilate (NaA) in the drinking water resulted in varying degrees of remission. In this series of tests 250 ppm AA in the feed or 175 ppm NaA in the water were the most effective in reducing the incidence of scours, lowering mortality, improving weight gains and improving feed efficiency. Feed consumption, while slightly lowered, was not sufficiently so as to preclude this medium as a route for medication.

¹ The authors are grateful to K. M. Prinz for his aid in the necropsy of animals in one of the experiments.

² Nutrition Research Department and Department of Infectious Disease.