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Metabolites of Progesterone and their Physiological Significance in the Urine of Pregnant and Non-Pregnant Sows and Gilts¹

University of Missouri, Columbia

Abstract

The urine of non-pregnant and pregnant sows was analyzed for pregnane derivatives by a modified Astwood and Jones technique. The procedure not only determined pregnanediol, which was originally present in the urine in a conjugated form, but also determined a ketonic and a non-ketonic constituent in the non-conjugated fraction. The highly significant correlations reported of the concentration, both of the conjugated and of the two non-conjugated fractions of sow pregnancy urine with the number of embryos implanted and with the percent of the ova resulting in viable embryos, indicate that all three metabolites are physiologically important in the reproductive processes associated with pregnancy in the sow.

¹ Departments of Animal Husbandry and Agricultural Chemistry, University of Missouri, Columbia.

² Missouri Agricultural Experiment Station, Tournal Series No. 2174.

³ Present address: Department of Chemistry, Kansas State University, Manhattan, Kansas.