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Response of Pigs Given Large Doses of Salmonella Choleraesuis to Sulfaguanidine, Nicotinic Acid, Thiamin and Pyridoxine¹

Michigan Agricultural Experiment Station²

Abstract

Thirty-six pigs were given a culture of Salmonella choleraesuis and also various combinations of supplements in an experiment designed to permit statistical analysis.

Sulfaguanidine was an effective drug in protecting the pigs from the S. choleraesuis.

Nicotinic acid did not prevent the pigs from reacting to the Salmonella but following an initial setback was effective in promoting rapid recovery and increased weight gains.

Vitamins B₁ and B₆ were not effective under the conditions of this experiment.

The results tend to substantiate previous observations that nicotinic acid is effective in preventing swine pellagra and in treating salmonellosis insofar as it enables the pig to maintain its body defenses but that it does not act as a bacteriostatic or bactericidal agent.

¹ Published with the permission of the Director of the Experiment Station as Journal Article No. 611 (n.s.).

² Sections of Chemistry and Animal Husbandry, East Lansing, Mich.