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The endocrine control of growth

University of California

Abstract

Conclusions: Hormones affecting both general body growth and the growth of specific organs are extracellular intermediate agents by which genetic constitution, nutrition, and physiological activity determine ultimate body size. Though postnatal growth is arrested promptly when growth hormone is withdrawn as in the hypophysectomized animal it seems clear that there are other agents controlling growth inasmuch as the results of chronic administration of growth hormone are distinctly limited. There is evidence that cells have varying inherent capacities for growth independent of extracellular influence. Though embryonic tissue from all species seems to have an inherent unlimited capacity to grow, heredity governs the development of an unknown factor which limits growth in postnatal life and accounts for the variations in growth amongst different species.