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The Partition of Calcium and Inorganic Phosphorus in Equine Serum

University of California, Davis¹

Abstract

Calcium is present in the serum in at least two distinct forms, the diffusible and non-diffusible fractions. The inorganic phosphorus of the sera of the dog and man is normally almost entirely diffusible, while in the sera of the chicken it exists in a diffusible and non-diffusible form. It is generally assumed that the diffusible fractions are more physiologically active than the non-diffusible fractions. Thus it is readily seen that a study of changes in the total calcium and total inorganic phosphorus only, may not be sufficient to give a complete picture of the states of these elements in the sera and of the factors influencing their levels. Conditions may arise in which the total serum calcium is at the lower limits of what is considered the normal range, and still the diffusible calcium may be reduced to as much as 50 per cent of the normal. This condition could be corrected by the administration of calcium, and might explain some obscure situations which arise in the mineral picture of the blood.

¹ This work was carried out at the W. K. Kellogg Institute Animal Husbandry, Pomona.