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Some Relations of Glutathione with Growth and Hereditary Size

University of California

Abstract

INTRODUCTION

Castle and Gregory (1) found that the embryological basis of size inheritance in the rabbit is dependent upon the rate of cell proliferation during prenatal development. Eggs of a large race segment at a faster rate than eggs of a small race. The eggs of hybrids between large and small races segment at an intermediate rate. Gregory and Castle (2) found, furthermore, that differences in rate of cell proliferation in eggs of a large race (Flemish) and a small race (Polish) could be detected as early as 40 hours after copulation. The studies indicated that the problem of size inheritance resolved itself largely into the physiology (or bio-chemistry) of cell division—rate of cell proliferation. Therefore any biochemical substance known to regulate cell proliferation and which is present in tissues may be involved in the problem of size inheritance. Our attention was first directed to sulfhydryl by the early work of Hammett (3, 4) who found that certain compounds containing the sulfhydryl (-SH) stimulated cell proliferation. Hammett and collaborators have produced an overwhelming mass of evidence to support his original hypothesis, and his observations have been confirmed, in part at least, by Voegtlin and Chalkley (5), Reimann (6, 7), Coldwater (8), and White (9).