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Production of Ovulation by Gonadotrophic Extracts

University of Wisconsin

Abstract

Ovulation in 22-day-old rats was not produced by either unfractionated extracts or purified follicular-stimulating extracts of sheep anterior pituitary. Corpora lutea atretica were present in the ovaries of seven rats treated with the former extract and only follicles in the ovaries of eight rats treated with the latter. Five out of eight rats ovulated upon being treated with a partially purified follicular-stimulating extract from which not quite all of the luteinizing activity had been removed.

Gelding anterior pituitary powder alone produced ovulation in nine out of fifteen animals from one strain of rats whereas the same powder produced almost exclusive follicular stimulation in sixteen animals from another strain. Addition of 22 mg. of luteinizing powder to the gelding pituitary powder inhibited ovulation with the formation of corpora lutea atretica in six animals of the first strain, whereas, the addition of 2 mg. produced ovulation in four out of six rats from the second strain. Nine mg. of the luteinizing powder inhibited ovulation with the formation of corpora lutea atretica in five of six animals from the latter strain.

Seventy-four tubal ova from eighty-three mg. ovaries and twenty-five tubal ova from one hundred twenty-six mg. ovaries were obtained in 22-day-old rats with mare pituitary extracts whose luteinizing activity had been reduced.

A partially purified follicular-stimulating extract alone produced ovulation in five out of seven juvenile rabbits. Of eight rabbits which were first treated subcutaneously with follicular-stimulator and then injected intravenously with from 8 to 22 mg. luteinizing powder, all had ovulated within forty-eight hours.

It is suggested that the luteinizing substance is necessary for ovulation of mature follicles but that if the luteinizing activity is too great, corpora lutea atretica will be formed with the enclosure of the eggs in the corpora.