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Selection for Natural Resistance to Cholera in Swine¹

Iowa State College

Abstract

During the past four years an attempt has been made at the Iowa Experiment Station to produce, by selective breeding of resistant individuals, a strain of hogs having a high natural resistance to cholera. Two other attempts to do this have been reported, one by Bureau of Animal Industry of the U. S. D. A.², and the other by Roberts³ at the University of Illinois. In both cases, the published results were incomplete and somewhat conflicting, and hence did not permit of any definite conclusions on the subject.

The work reported herein was undertaken because it has long been known that a few pigs are apparently completely refractory to the disease during acute epidemics of cholera, and, likewise, that a small percentage of the pigs used by serum plants for the production of virus never react following heavy injections of potent cholera virus. Such pigs apparently possess a high natural resistance to the disease, for in some instances such individuals were definitely known not to have been artificially immunized against cholera.

¹ Paper No. 27-Dept. of Genetics, Iowa State College, in co-operation with the Departments of Veterinary Investigation and Animal Husbandry.

This investigation was undertaken at the suggestion of Dr. E. W. Lindstrom and much credit is due him for kindly criticism and advice.