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A Technique for Assay of Goitrogens in Feed¹

University of Missouri, Columbia

Abstract

An assay procedure has been described which can be used to detect minute amounts (0.5–2 ppm.) of residues in tissues of goitrogen-fed animals. The technique described in rats consists in determining 24-hour I₁₃₁ uptake after feeding the goitrogen (or tissues) for a period of 4 days and then comparing it with control I₁₃₁ uptakes. A low-iodine diet, by enhancing I₁₃₁ uptake, increased the sensitivity of the assay technique. By this method, tapazole at 0.00005–0.0002% (–2 ppm.) and carbimazole at 0.0001–0.001% (1–10 ppm.) in low iodine feed could be detected as shown by reduced I₁₃₁ uptake in comparison with controls.

¹ Contribution from Mo. Agr. Exp. Sta. Department of Dairy Husbandry. Journal Series No. 2163. Approved by the Director.