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Availability of Copper to Sheep from Cu-64 Labeled Inorganic Compounds¹

University of Tennessee-Atomic Energy Commission, Agricultural Research Laboratory, Oak Ridge, Tennessee

Abstract

Blood and plasma concentrations after oral administration were greater (P<0.05) from the chloride source than from the sulfate, nitrate or cupric oxide needles sources of Cu~64. Cumulative fecal or urinary excretions from the chloride, nitrate or sulfate forms did not differ but exceeded (P<0.01) excretions from the cupric oxide needles.

In a subsequent experiment, the blood and plasma concentrations were significantly greater from the oral carbonate source than from the oxide sources. Cumulative fecal excretion from the cupric oxide powder was significantly greater than from the cupric carbonate, while cumulative urine excretion from the cupric carbonate was significantly greater than from the other sources.

Intravenous injection of radioactive copper-64 in the form of the chloride, nitrate or sulfate showed cumulative excretion in the urine to be greater (P<0.01) from the chloride source than from the nitrate or sulfate.

¹ Published with the approval of the Directors of the Tennessee Agricultural Experiment Station and the Georgia College Experiment Station. The Radioactive materials used in this work were obtained from the Oak Ridge National Laboratory on allocation from the United States Atomic Energy Commission. This study was completed under Contract No. AT-40-1-GEN-242 between the University of Tennessee College of Agriculture, and the Atomic Energy Commission.

² Research participant, Oak Ridge Institute of Nuclear Studies, on leave from the University of Georgia, Athens, Georgia. The authors are grateful to Mr. R. C. McIlhenny, Radiochemist, UT-AEC Agricultural Research Laboratory, for radiochemical assistance, and to Dr. J. L. Carmon, statistician, Georgia College Experiment Station, for conducting the statistical analyses.