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Studies on Serum Proteins of Normal and Parakeratotic Pigs¹

University of Wisconsin,³ Madison

Abstract

Studies of the blood serum proteins of parakeratotic pigs compared to normal pigs showed that there was no change in total serum protein, that there was a definite decrease in the albumin:globulin ratio, and that this was brought about mainly by a decrease in albumin with a parallel increase in gamma-globulin. The amounts of alpha- and beta-globulins were essentially the same for normal and parakeratotic pigs. The altered serum electrophoretic pattern was not a good diagnostic aid for parakeratosis, since there appeared to be other factors which altered the pattern in the same direction as did parakeratosis. It is suggested that zinc deficiency, per se, is not directly involved in the altered serum protein pattern of parakeratotic pigs but that such alterations result instead from an increased susceptibility to invasion by infectious agents.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station, Madison. This work supported in part by a grant from the American Cyanamid Co., Pearl River, New York.

² This material is based upon part of a thesis submitted by the senior author in partial fulfillment of the requirements for the Ph.D. degree at the University of Wisconsin. Present address: Nutrition Research Department, Abbott Laboratories, North Chicago, Illinois.

³ Departments of Animal Husbandry and Biochemistry, Madison.