HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Premachandra, B. N. Articles by Turner, C. W. Search for Related Content PubMed Articles by Premachandra, B. N. Articles by Turner, C. W.

Comparative Goitrogenic Activity of Tapazole and Carbimazole in Cattle¹

University of Missouri, Columbia

Abstract

The comparative goitrogenicity of two compounds, tapazole (1-methyl, 2-mercaptoimidazole) and carbimazole (1-methyl, 2-thio, 3-carbethoxyi-midazole) was determined in cattle by I¹³¹ uptake suppression and by I¹³¹ release measurements. By the former measurement carbimazole and tapazole were found equipotent and 3 gm./1000 lb. body weight completely blocked thyroxine secretion. By I¹³¹ release rate measurements, however, carbimazole was about twice as potent as tapazole in blocking thyroxine synthesis. The implications of the differences in the potency of the goitrogens by different techniques are discussed.

¹ Contribution from Mo. Agr. Exp. Stat., Journal Series No. 2081. Approved by the Director.

² Aided in part by a grant from the U. S. Atomic Energy Commission (Contract No. AT(11-1)-301). The supply of tapazole from Eli Lilly & Co., Indianapolis, and of carbimazole from Denver Chemical Co., Stamford, Conn., is gratefully acknowledged.