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Excretion Studies in Swine Fed Arsanilic Acid

Abbott Laboratories^,2, North Chicago, Illinois

Abstract

The rates of arsenic excretion were determined in the feces and urine of swine receiving arsanilic acid at 30, 60 and 90 gm. per ton of feed. Much more arsenic was excreted in the feces than in the urine. After 10 days of arsanilic acid feeding, total excretion was in approximate balance with intake at the two lower levels of feeding. After the arsenical was withdrawn from the ration, the characteristic excretion level continued for two days, then decreased rapidly. This conforms with knowledge of the rate of disappearance of arsenic from tissues of animals fed arsanilic acid. The nature of the major part of the arsenical excreted was not determined. Unchanged arsanilic acid was not detected in the urine, but was present in the feces in an amount representing about 5% of the arsanilic acid consumed.

¹ The authors are grateful to L. E. Hanson, J. M. Russo and J. J. Jezeski, University of Minnesota, for supplying us materials from their experiments which made this study possible.

² Nutrition Research Department.