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Hypoglycemic Compounds as Appetite Stimulants for Baby Pigs¹

Florida Agricultural Experiment Station, ³ Gainesville

Abstract

A series of eight experiments involving 162 early weaned baby pigs was conducted in an attempt to determine if feed consumption could be stimulated by experimental hypoglycemia.

Tolbutamide failed to produce hypoglycemia; therefore, no conclusive results were obtained regarding the relationship between blood glucose concentration and feed consumption. Tolbutamide demonstrated active hypoglycemic properties when administered orally by capsule to fasted pigs (500 or 1000 mg./pig). When mixed in the ration at the rate of 800 mg. per lb. it reduced rate of growth significantly. It did not appear to be toxic at the levels studied.

Insulin injected in one experiment at the rate of 0.5 and 1.0 unit per kg. body weight every 12 hours produced hypoglycemia and also reduced feed consumption and rate of gain.

Feed consumption and average daily gains were not stimulated by any of the treatments studied.

¹ Florida Agricultural Experiment Station Journal Series, No. 893. Appreciation is expressed to the Upjohn Co., Kalamazoo, Michigan for the supply of tolbutamide and to the Eli Lilly and Co., Indianapolis, Indiana for the insulin used in the study.

² Present address: Department of Animal Husbandry, Iowa State College, Ames.

³ Department of Animal Husbandry and Nutrition.