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Failure to Detect Residual Estrogenic Activity in the Edible Tissues of Steers Fed Stilbestrol

U. S. Department of Health, Education, and Welfare, Washington, D. C.^,2

Abstract

No added estrogenic activity could be detected in the edible tissues of steers fed 10, 30, and 60 mg. of stilbestrol per steer per day for 90 to 180 days when the stilbestrol was removed from the feed 48 hours before slaughter. The method used was capable of detecting 2 parts per billion in stilbestrol equivalents in every case, and often as low as 0.5 parts per billion. The failure to detect estrogenic residues in the edible tissues of one steer fed at the rate of 30 mg. per day and another at the rate of 60 mg. per day, when the feed was removed 48 hours before slaughter, provides a safety factor for the possible misuse of the products.

¹ The authors gratefully acknowledge the technical assistance of Mr. Leonard J. Davis in the preparation of the diets and the care and feeding of the mice used in these experiments.

² Division of Pharmacology, Bureau of Biological and Physical Sciences, Food and Drug Administration.