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Effects of Dietary Stilbestrol upon Certain Endocrine Organs in Lambs¹

University of Tennessee—Atomic Energy Commission Agricultural Research Program^,4

Abstract

Investigations were conducted to study the interrelationship between dietary stilbestrol and certain endocrine organs and their products using growing wether lambs. Stilbestrol feeding significantly increased pituitary weights, and appreciably increased adrenal weights. When these weights were correlated with body weight, the stilbestrol-fed lamb pituitaries were still significantly larger than their controls. When adrenal weights were correlated with body weight, no differences were observed. Adrenal cholesterol levels, interpreted as being indicative of adrenal function, were significantly higher in the stilbestrol-fed lambs. Stilbestrol feeding resulted in a significant increase in pituitary growth hormone. Gonadotropin levels were significantly reduced as a result of estrogen feeding. Hormone administration, however, apparently had little influence upon pituitary levels of1 ACTH and thyrotropin.

¹ Data presented herein were taken from a dissertation presented by the senior author to the Graduate School, Oklahoma State University, in partial fulfillment of requirements for the degree of Doctor of Philosophy.

² Formerly Graduate Fellow, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee. Present Address: Department of Animal Husbandry, Iowa State College.

³ Present Address: Department of Animal Industry, Louisiana State University.

⁴ This manuscript is published with the approval of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville, Tennessee. The radioactive materials used in this work were obtained from the Oak Ridge National Laboratory on allocation from the United States Atomic Energy Commission. This work was completed under Contract No. AT-40-1-GEN-242 between the University of Tennessee, College of Agriculture and the Atomic Energy Commission.