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Ascaricidal Activity of Piperazine Administered in the Feed to Swine

Research Division, Hess And Clark, Inc., Ashland, Ohio

Abstract

Three simple piperazine compounds, piperazine sulfate, piperazine dihydrochloride and piperazine phosphate were given at different levels in the feed for 24 hours to 81 parasitized hogs. The three drugs were equally acceptable when given in the feed without a prior fast period. When fed at levels which furnished an equivalent amount of anhydrous piperazine in the feed, the dihydrochloride and the phosphate were slightly superior to the sulfate in ascaricidal activity.

Six pigs given 0.44% piperazine sulfate in the feed for 24 hours, consumed an average of 51.8 mg. piperazine per pound of body weight and eliminated 92.4% of 119 Ascarids. Twelve pigs given 0.4% piperazine dihydrochloride in their feed for the same period of time eliminated 98.1% of 310 Ascarids with a mean dosage of 52 mg. piperazine per pound of body weight. At a concentration of 0.49% in the feed, piperazine phosphate removed 100% of 115 Ascarids from 7 pigs which consumed an average of 54.2 mg. piperazine per pound of body weight.