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The Influence of Chlortetracycline on the Requirement of the Young Pig for Dietary Pantothenic Acid¹

Florida Agricultural Experiment Station²

Abstract

Five-week-old weanling pigs in drylot developed pantothenic acid deficiency symptoms on a 14% crude protein basal ration composed of ground corn, soybean oil meal, minerals and supplemented with vitamins, except for pantothenic acid. Supplementation of this ration with either pantothenic acid or chlortetracycline prevented the development of deficiency symptoms.

Pigs initially weighing 16 lb. developed more severe deficiency symptoms than pigs initially weighing 20 lb. Possible explanations for this difference in response are discussed.

Although not a sensitive criterion, concentration of pantothenic acid in the liver seemed to reflect more accurately the pantothenic acid status of the animals than levels of this vitamin in the brain, heart or kidney. Age and ration influenced the liver and kidney level of pantothenic acid.

Under the conditions imposed, chlortetracycline at the level of 10 mg. per lb. of ration appeared to have a sparing effect on the dietary pantothenic acid requirements of weanling pigs.

¹ Florida Agriculture Experiment Station Series No. 515.

² Department of Animal Husbandry and Nutrition.This study was supported in part by a rant from the American Cyanamid Co.