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Residual Estrogen in the Tissues of Cattle Treated Orally with Diethylstilbestrol, Dienestrol, Hexestrol and Chlortetracycline¹

Purdue University Agricultural Experiment Station²

Abstract

Estrogenic residues were detected in the muscle, kidney fat, kidney, intestine and liver of cattle treated orally with diethylstilbestrol. Residual estrogenic activity was present in the kidney, kidney fat, intestine and liver of cattle following oral treatment with dienestrol. The oral administration of hexestrol to cattle resulted in the retention of estrogen only in the kidney and kidney fat of these animals.

The oral administration of chlortetracycline in combination with hexestrol had no apparent effect on the degree of residual estrogenic activity.

The minimum length of time required for the uterus of the castrated female mouse to respond statistically significantly to a minute amount of orally administered diethylstilbestrol is three days.

¹ Contribution from the Department of Animal Husbandry, Journal Paper No. 977.

² Lafayette, Indiana.

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