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N,N¹-Diphenyl-P-Phenylenediamine in the Prevention of Vitamin E Deficiency in the Lamb

Division of Animal Nutrition, University of Illinois, Urbana

Abstract

Newborn lambs were maintained on an artificial milk diet containing tocopherol-free lard as a source of fat. The effectiveness of N,N¹-diphenyl-p-phenylenediamine (dppd) in preventing the occurrence of clinical and histological signs of muscular dystrophy was determined. Administration of dppd at a level equivalent to 0.10% of the dry matter content of the diet completely prevented the appearance of vitamin E deficiency. A level of 0.025% was found to be slightly inadequate and 0.001 % was ineffective.

¹ This project was supported in part by a grant from Armour and Company, by a gift of vitamins from Merck and Co., Inc., and by a supply of N,N¹-diphenyl-p-phenylenediamine from B. F. Goodrich Chemical Company.

² Courtesy of U. S. Garrigus.