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The Effect of Organic Arsenicals, Chlortetra-Cycline and Linseed Oil Meal on Selenium Poisoning in Swine

South Dakota Agricultural Experiment Station

Abstract

Two experiments involving a total of 88 pigs were conducted to determine the effectiveness of organic arsenicals, linseed oil meal and chlortetracycline in counteracting the effects of chronic selenium poisoning in pigs. Arsanilic acid at a level of 0.01% gave good protection against up to 13 p.p.m. of selenite selenium while 3-nitro-4-hydroxyphenylarsonic acid (.005%) gave its best protection when used in combination with linseed oil meal.

In one experiment linseed oil meal protected against the visible signs of selenium toxicity but did not alter the rate of gain of pigs fed selenized rations. This protection was evidenced whether the linseed oil meal was fed alone or in combination with either of the organic arsenicals, although the combination of linseed oil meal and organic arsenical gave the best protection.

In a second experiment chlortetracycline did not protect against selenium poisoning but it did increase the growth rate of those pigs fed a combination of arsanilic acid and chlortetracycline.

¹ Contribution from the Departments of Animal Husbandry and Station Biochemistry and approved for publication by the Director of the Agricultural Experiment Station, College Station. Publication No. 344 of the Journal Series.

² Grateful acknowledgement is made to Abbott Laboratories, North Chicago, Illinois, for funds and arsanilic aicd; to Dr. Salsbury's Laboratories for the 3-nitro-4-hydroxyphenylarsonic acid; to American Cyanamid Co., Pearl River, N. Y. for chlortetracycline; and, to Merck & Co., Rahway, N. J. for the B-vitamins.