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Some Effects of Purified Anterior Pituitary Growth Hormone on Swine^{1, 2}

Purdue University Agricultural Experiment Station

Abstract

Pigs injected daily with three different purified growth hormone preparations gained at a slightly, but not significantly, faster rate, consumed significantly less feed per day, and required significantly less feed per unit of gain than did non-injected pigs.

The carcasses of growth hormone injected pigs contained significantly more protein and moisture, and less fat than did the carcasses of control pigs.

Daily injections of growth hormone in swine resulted in significant increases in blood glucose, slight, but not significant, increases in blood inorganic phosphorus, and decreased blood non-protein nitrogen. The anterior pituitary glands of pigs injected daily with growth hormone contained significantly more of the thyrotropic and gonadotropic hormones than did the pituitaries of control pigs.

¹ Contribution from the Department of Animal Husbandry, Journal Paper No. 802, Purdue University Agricultural Experiment Station in cooperation with the Regional Swine Breeding Laboratory, Ames, Iowa, Bureau of Animal Industry, U.S.D.A.

² A portion of the thesis presented to the Graduate Faculty at Purdue University by the senior author in partial fulfillment of the requirements for the degree of Doctor of Philosophy, August 1953.

³ The authors express their appreciation to Dr. Irby Bunding, The Armour Laboratories, Chicago, Illinois for the purified growth hormone.

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